Autoimmune attack underlying kidney failure

Autoimmune DiseasesInterstitial nephritis, a common cause of kidney failure, has a complex and largely unknown pathogenesis. In a new published paper in The Journal of the American Society of Nephrology (JASN), a team of researchers led from Karolinska Institutet shows how interstitial nephritis can develop from an autoimmune attack on the kidney’s collecting duct.

Interstitial nephritis describes a type of morbid lesion often seen in patients with kidney failure that is characterised by tubular atrophy and interstitial scarring. The condition can develop from diverse backgrounds, such as adverse reactions to drugs, hypertension and diabetes; in many patients, however, the underlying cause is never identified. Continue reading “Autoimmune attack underlying kidney failure”


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